A neuronal death model: overexpression of neuronal intermediate filament protein peripherin in PC12 cells
نویسندگان
چکیده
منابع مشابه
Overexpression of neuronal intermediate filament protein α -internexin in PC 12 cells
The neuronal intermediate filaments include not only the neurofilament triplet proteins but also peripherin and α-internexin. To determine whether neurite outgrowth is enhanced by α-internexin, the cDNA of rat α-internexin tagged with enhanced green fluorescent protein (EGFP) was transfected into a rat adrenal pheochromocytoma cell line PC-12 that responds to nerve growth factor (NGF) by induct...
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Intermediate filament (IF) overproduction induces abnormal accumulation of neuronal IF, which is a pathological indicator of some neurodegenerative disorders. In our study, α-Internexin- and peripherin-overexpressing PC12 cells (pINT-EGFP and pEGFP-peripherin) were used as models to study neuropathological pathways responsible for neurodegenerative diseases. Microarray data revealed that Cdk5-r...
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Background and Objective: Biomaterials and nanomaterials have generated a great opportunity in regenerative medicine. Neurological disorders can result in permanent and severe derangement in motor and sensory functions. This study was conducted to examine the effects of selenium nanoparticles (Se NPs) as a chemical inducer for differentiation of PC12 cells into sympathetic-like neurons characte...
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The human T-cell leukemia virus (HTLV) is associated with adult T cell leukemia and neurological disorders (TSP/HAM). The HTLV transcriptional transactivator, Tax, is known to exert its effect through protein-protein interaction with several transcription factors that activate genes in T cell proliferation. The pathogenic mechanism in the CNS is less defined. Using the yeast two-hybrid system, ...
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The human neuronal apoptosis inhibitory protein (NAIP) gene has been discovered as a candidate gene for spinal muscular atrophy, a genetic disorder characterized by motor neuron loss in the spinal cord. The telomeric NAIP gene on human chromosome 5 is deleted together with survival motor neurons (SMN) in many cases of the most severe forms of the disorder. NAIP, c-IAP1 (inhibitor of apoptosis-1...
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ژورنال
عنوان ژورنال: Journal of Biomedical Science
سال: 2012
ISSN: 1423-0127
DOI: 10.1186/1423-0127-19-8